Celebrex

The main operating component of the capsule Celebrex suppresses (inhibits) the activity of the enzyme cyclooxygenase-2 (COX-2, which is secreted by the cells of the immune system during the development of the inflammatory process and catalyzes the reaction of transformation of arachidonic acid into the inflammatory mediators prostaglandins.


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Description

The main active ingredient of the drug is celecoxib, its content in each capsule is 200 or 400 mg.

Pharmacological effects

The main operating component of the capsule Celebrex suppresses (inhibits) the activity of the enzyme cyclooxygenase-2 (COX-2, which is secreted by the cells of the immune system during the development of the inflammatory process and catalyzes the reaction of transformation of arachidonic acid into the inflammatory mediators prostaglandins. The data of biologically active compounds lead to the development of signs of inflammation which include pain, tissue swelling and hyperemia. Since the drug blocks the enzyme COX-2, its main pharmacological effect is to reduce the concentration of prostaglandins in the hearth of the pathological process and characteristics of the inflammatory response, primarily pain. Also, the drug has anti-inflammatory and antipyretic therapeutic effects. Сelebrex can be bought on our website.

After taking the capsules of Сelebrex inside, the current component is quickly and almost completely absorbed into the systemic circulation. It is evenly distributed in tissues, crosses the blood-brain barrier in the structures of the central nervous system. Celecoxib is metabolized in the liver to form inactive breakdown products that are excreted in the urine.

Indications for use

Сelebrex can be bought on our website.

The reception of Сelebrex is prescribed for the treatment of various inflammatory diseases, as well as reducing the severity of pain:

Back pain.

Pain after surgeries.

Symptomatic treatment is aimed at reducing the severity of inflammation in the pathology of the structures of the musculoskeletal system – rheumatoid arthritis (an autoimmune lesions of the joints), osteoarthritis (degenerative-dystrophic lesions of the joints, accompanied by the development of inflammatory reactions).

Also the drug is used for treatment of primary algodismenorea of women (menstruation, accompanied by severe pain).

Drug Contraindication

It involves a range of pathological and physiological states of the patient, which prohibits the taking the capsules of Сelebrex, these include:

Inflammatory pathology of the intestine.

Pathology of peptic ulcer or peptic gastric ulcer, duodenal ulcer of the acute stage.

Severe renal or hepatic insufficiency.

Condition after surgical procedures of coronary artery bypass grafting.

Marked insufficiency of the functional activity of the heart.

Confirmed coronary heart disease, peripheral artery or cerebrovascular pathology.

Confirmed patient’s sensitivity to drugs of pharmacological group of sulfonamides.

Specific allergic reactions (asthma, urticaria) developing after use of aspirin or other drugs of the pharmacological group of non-steroidal anti-inflammatory drugs.

Hypersensitivity to the active component or auxiliary compounds of this drug.

Pregnancy in any trimester, as well as the period of breastfeeding (lactation).

The patient’s age to 18 years.

The drug is used with caution after suffering from ulcerative pathology of the structures of the gastrointestinal tract, and in the background of remission of the pathological process (improvement of clinical and laboratory parameters of the disease), in case of joint use of medicinal products of anticoagulants and antiplatelet agents, which reduce blood clotting, diabetes, heart disease and blood vessels, cerebrovascular diseases, severe somatic pathology, pathology of peripheral arteries. It is important to ensure the absence of contraindications before taking capsules of Сelebrex

Dosage

Capsules of Сelebrex can be bought on out website. Celebrex is intended for oral administration with or without food. They are not chewed but washed out plenty of water. It is recommended to use the drug in the minimum effective therapeutic dose and a small course in order to reduce the likelihood of adverse pathological reactions, in particular, of the cardiovascular system. If you need to hold longer course of treatment, the maximum daily dosage of capsules Сelebrex should not exceed 400 mg. The mode of medication, as well as the average therapeutic dose depends on medical indications.

 

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