Codeine

The pharmacological activity of the substance is mostly approximate to morphine, but its analgesic effects are less pronounced. The drug depresses the cough reflex and respiratory depression is less pronounced than with other drugs of this group. There were known cases of paradoxical excitation of the nervous system after ingestion of Codeine, which are accompanied by insomnia.


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Description

Pharmacological action.

The pharmacological activity of the substance is mostly approximate to morphine, but its analgesic effects are less pronounced. The drug depresses the cough reflex and respiratory depression is less pronounced than with other drugs of this group. There were known cases of paradoxical excitation of the nervous system after ingestion of Codeine, which are accompanied by insomnia. You may buy Codeine on the website.

The drug is an agonist of mu-opiate receptors and has the ability to depress the work cough center, to excite the opioid receptors in peripheral tissues and different parts of the nervous system. The use of the receptors of this kind on the periphery is associated with activation of antinociceptive system and the change in the mechanism of perception of body pain.

The substance is generally better tolerated than morphine, distinctive side effects develop rarely. However, opiate receptors, that are located in the gut, relaxes the smooth muscles, sphincters, reduce peristalsis.

The analgesic effect from the medication can be observed within 30 minutes hours after oral use and within 10-40 minutes after subcutaneous or intramuscular injection. Maximum effectiveness comes after an hour or two after taking the pills and in 30-60 minutes after injection. Analgesia is maintained at peak level for 4 hours. Cough reflex does not occur up to 6 hours.

After intake the remedy is rapidly absorbed from the gastrointestinal tract, has a slight degree of binding to plasma proteins. Metabolism occurs in the liver, where about 10% is converted to morphine. The half-life is from 2.5 to 4 hours. A small amount of medication is excreted through the kidneys in unchanged state, 10% — in the form of morphine, the rest is metabolites.

Indications for use

Tablets with Codeine are used to eliminate the weak and moderate pain syndrome (headache, neuralgia, trauma, cramps) and diarrhea. Most often the composition of tablets additionally includes non-narcotic analgesics. Also there are drugs for cough with Codeine in case of nonproductive cough (bronchitis, emphysema, pneumonia). Codeine can be purchased on our website in any quantity.

Drug Contraindications

The drug is contraindicated:

if you are allergic to Codeine or other substances in the composition;

to patients with toxic dyspepsia;

as antidiarrheal remedies, if the diarrhoea is caused by pseudomembranous colitis due to ingestion of other drugs;

in case of acute bronchial asthma or other respiratory depression;

to children up to one year.

Caution should be exercised:

if it developed acute abdominal pain of unknown origin before or during the treatment;

in chronic obstructive pulmonary disease;

if a patient has a tendency to seizures;

in case of arrhythmia;

during treatment of elderly patients;

alcoholics and patients with drug dependency in the past;

to patients who are prone to suicidal behavior;

with increased emotional lability;

to patients with gallstone disease or if you have recently conducted operations on the urinary system and the gastrointestinal tract;

after a brain injury;

when increased intracranial pressure;

to patients with kidney and liver disorders;

in case of hypothyroidism;

during the treatment of debilitated and seriously ill persons;

when prostatic hyperplasia;

to pregnant women;

in case of cachexia;

in the period of breast-feeding;

while taking MAO inhibitors or other medications that are incompatible with Codeine;

to children.

Side effects

The treatment with Codeine sometimes causes undesirable side effects. Most often they are constipation and drowsiness.

Less often it may develop:

dry mucous membranes, nausea, cramps in the gastrointestinal tract, anorexia, vomiting, paralytic ileus;

flatulence, cramps in the bile ducts;

dizziness, fatigue, hallucinations, blurred vision, depersonalization;

paradoxical reaction (often in children), anxiety, psychomotor agitation and insomnia;

cardiac arrhythmia, low blood pressure;

sweating, the alleged rise of vitality, discomfort and irritability;

respiratory depression, until the collapsed lobe of the lung;

the recent decrease in urine output, pain and difficulty when urinating;

allergic reactions, skin rash and itching, hives, swelling, laryngeal edema, broncho – or laryngospasm.

Rarely it can occur:

toxic liver damage, gastralgia;

nightmares and restlessness during sleep, depression, convulsions, tremor;

the sharp rise of tonus of the respiratory muscles, involuntary twitching, ringing and noise in the ears;

increase in blood pressure;

increased tone of smooth muscles, atony of the bladder;

the increase in body weight or weight loss.

It should also be noted that during the treatment it can develop drug dependence, tolerance to the drug. The cessation of therapy may cause withdrawal syndrome.

The usage instructions (Method and dose)

Depending on the disease and the composition of drug, the dosage and treatment scheme are different and determined by your doctor.

The usage instruction of Codeine for adults

Patients take from 15 to 60 mg of the drug every 3-6 hours for the relief of pain.

It is taken at the dose of 30 mg 4 times a day as an antidiarrheal means.

If you want to resolve cough, it is enough to use 10-20 mg the drug 4 times a day.

The maximum daily dosage for an adult is 120 mg of Codeine.

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