A person can safely live, go to work, do household chores and feel normal, when suddenly, after giving a biochemical blood test, he is diagnosed with hyperlipidemia. This medical term means a high content of low-density lipoproteins in the bloodstream. In other words, a person has an abnormally elevated level of fat fractions – cholesterol and triglycerides. The insidiousness of this pathology lies in the fact that it proceeds asymptomatically, but significantly increases the risk of atherosclerotic plaques and the development of cardiovascular diseases. When clogging the cerebral vessels, a stroke can occur, with the growth of a plaque in the coronary arteries – a heart attack. To prevent such life-threatening pathological conditions, the level of cholesterol must be urgently reduced. In such cases, people are “put” on the hypocholesterolemic diet and prescribe the intake of special medicines. Among them is the preparation Crestor. Instruction for use notes that this is a powerful lipid-lowering agent, the active ingredient of which is rosuvastatin – a substance from the group of statins of the last (fourth) generation.
Mechanism of action
In its essence, this medicine belongs to selective inhibitors of the microsomal enzyme HMG-CoA reductase. This enzyme takes a direct part in the formation of melavonate, an intermediate substance of the biological synthesis of cholesterol. This reaction limits the rate of production of cholesterol compounds. HMG-CoA reductase is present in the cells of various cholesterol producing organs (for example, the adrenal glands, the small intestine), but the main effect of the Crestor drug is directed at inhibiting the enzyme present in the liver. Under the influence of this medication, the catabolic disintegration of low-density lipoproteins is enhanced. In the end, there is a significant decrease in the level of cholesterol and triglycerides. The first positive results are observed a week after the start of the drug. In the future, the drug will need to be taken regularly to achieve the maximum therapeutic effect and its maintenance.
Indications for use
The varieties of hyperlipidemia are classified by the name of the American doctor-researcher Donald Fredrickson. There are five types of hypercholesterolemic condition. The drug Crestor is prescribed for the treatment of pathologies belonging to types 2-a, 2-b and 4 according to Fredrickson. These include primary, mixed, family homozygous hyperlipidemia, as well as hypertriglyceridemia. In addition, this medication is used for preventive purposes with an increased risk of atherosclerosis, hypertension, coronary heart disease in people over 50 years of life.
Conditions for admission
It should be noted that without strict adherence to a special hypocholesterolemic diet, the drug Crestor will be ineffective. Tablets are taken daily, once a day, at any time of the day. The attending physician selects the dose individually for each patient. Usually in the first month of admission 5 – 10 milligrams of the drug is prescribed. After this time, the level of total cholesterol, low-density lipoproteins and triglycerides is checked. Based on the indices of lipid metabolism, the dose can be increased.
Crestor is a potent drug, so you should carefully consider its contraindications. Medication can’t be taken with pronounced renal and hepatic insufficiency, thyroid diseases, myopathy (hereditary neuromuscular disorder), lactose intolerance, hypersensitivity to drugs from the drug group of statins. It is forbidden to use this lipid-lowering drug for women during pregnancy and breastfeeding of a child, as well as children and adolescents under the age of 18 years.
Despite the high therapeutic effectiveness of statins of the latest generation, side effects have not been avoided by the drug Crestor. Instruction for use indicates such negative manifestations as dyspepsia disorders of the digestive tract, headache, cough, muscle spasms, edema, peripheral nerve damage (polyneuropathy), insomnia, skin allergic reactions.
If you follow a diet and a healthy lifestyle, Crestor medicine will definitely help you cope with lipid lowering, but remember that this medication is not meant for self-medication.