According to statistics the most common cause of death remains cardiovascular disease, which includes hypertension. Patients with the disease have to regularly take medicines to reduce blood pressure, which in addition to tangible benefits, cause serious harm to the body. In this respect, Diovan highlights among the group of anti-hypertensive drugs, the instructions for use is given in this article.
Diovan is a peripheral vasodilator which has a hypotensive effect and effectively regulates blood pressure. This medication is composed of two main ingredients: valsartan and hydrochlorothiazide. The medicine is available in the form of tablets, film-coated. Depending on the desired therapeutic effect, tablets of Diovan are produced in the following proportions valsartan and hydrochlorothiazide: 160mg/25mg; 160mg/12.5 mg and 80 mg/12.5 mg.
The mechanism of action of the drug is based on its major substances.
After the injection valsartan dilates small blood vessels and lowers blood pressure without any effect on pulse rate. Hydrochlorothiazide is a diuretic substance of medium strength, which promotes the excretion of magnesium and potassium ions. Tablets are well-absorbed by the walls of the stomach and within 1-2 hours the patient feels their beneficial effects, i.e. the increase of the diuretic effect and lower blood pressure.
Indications for use of the drug note that the drug is firstly used in case of hypertension. In this case, the drug is taken at the dosage of 80 mg once a day. In case of the absence of therapeutic effect your doctor may increase the dosage to 160 mg.
In case of heart failure, vasodilator is taken at the dosage of 40 mg twice a day. In case of the absence of a therapeutic effect specialist can increase the dosage by half, but the dose should be increased gradually. The maximum daily dose, if necessary, and good tolerability of the drug should not exceed 320 mg/day. Often, Diovan is used in conjunction with other drugs, recommended for admission with heart failure.
Patients with acute myocardial infarction are recommended to start the treatment after 12 hours after an acute condition with stable hemodynamics. The drug is assigned with an initial dosage of 20 mg per day and then the dose needs to be increased to 320 mg in two steps. Treatment in myocardial infarction lasts at least three weeks.
Among the contraindications to the medication, the instruction highlights the following: severe renal failure, hepatic impairment, breastfeeding, the period of carrying a child, lactose intolerance, age up to 18 years of hypersensitivity to valsartan, hydrochlorothiazide and other components of the drug.
The side effects of the drug include the following: abdominal pain, dizziness, unexplained cough, nausea and vomiting, constipation or diarrhea, increased creatinine and potassium in the blood, pain in the joints, development of vasculitis, impaired renal function, and allergic reactions (rash, urticaria, angioedema). A symptom of drug overdose can be a serious decrease in blood pressure, even loss of consciousness. In this state, you should immediately perform the gastric lavage, take activated charcoal tablets and intravenously enter a solution of sodium chloride.