Etodolac

The NSAID, an indoleacetic acid derivative, has a tetrahydropyranoside nucleus in the composition. Has anti-inflammatory, analgesic, antipyretic effect.
Oppresses the synthesis of prostaglandins in the inflammatory focus, so the drug reduces the sensitivity of pain receptors to inflammatory mediators, such as histamine, serotonin, kinin.
Eto-lactol inhibits COX and suppresses the synthesis of prostaglandins from arachidonic acid. In addition, the drug has a uricosuric effect.


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Description

The pharmacological action of Etodolac.

The NSAID, an indoleacetic acid derivative, has a tetrahydropyranoside nucleus in the composition. Has anti-inflammatory, analgesic, antipyretic effect.
Oppresses the synthesis of prostaglandins in the inflammatory focus, so the drug reduces the sensitivity of pain receptors to inflammatory mediators, such as histamine, serotonin, kinin.
Eto – lactol inhibits COX and suppresses the synthesis of prostaglandins from arachidonic acid. In addition, the drug has a uricosuric effect.
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Indications for use Etodolac.

Rheumatoid arthritis, ankylosing spondylitis, arthrosis with pain syndrome and restriction of movements, acute and chronic osteoarthritis.
Dosage regimen of Etodolac.
It is taken inside at a daily dose of 400-1200 mg, the frequency of reception – 2 times / day (morning and evening). The maximum daily dose is 1200 mg.
For patients with a body weight of 60 kg or less, the maximum daily dose is 20 mg / kg.

Side effect of Etodolac

On the part of the digestive system: nausea, epigastric pain, diarrhea, flatulence, constipation, transient elevation of hepatic transaminase activity.
Allergic reactions: skin rash, itching.
From the respiratory system: bronchospasm (in patients with the “aspirin triad”).
From the side of the central nervous system: dizziness, headache, fatigue.

Contraindications for Etodolac

Peptic ulcer of the stomach and duodenum; history of bronchial asthma, rhinitis, urticaria, developed after taking acetylsalicylic acid or other NSAIDs; pregnancy; lactation (breastfeeding); hypersensitivity to Etodolac
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Important information

 Pregnancy and lactation.

 It is contraindicated in pregnancy and lactation (breastfeeding).

 Application for violations of hepatic function

 In patients with cirrhosis of the hepatic, chronic hepatic failure requires monitoring of hepatic and kidney function at the beginning of treatment.

 Application for violations of kidney function

 Patients with chronic renal failure need to monitor hepatic and kidney function at the beginning of treatment.

 Application in old age

 Older patients need to monitor hepatic and kidney function at the beginning of treatment.

 Application for children

 It should not be used in children under 15 years of age.

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Special instructions.

Etodolac can inhibit platelet function, especially in patients taking anticoagulants; in such cases, regular clinical monitoring is required. The treatment is stopped if bleeding develops.

In patients with heart failure, cirrhosis, chronic renal or hepatic insufficiency, during treatment with diuretics, as well as in elderly patients, control of hepatic and kidney function at the beginning of treatment is necessary.

When determining the level of bilirubin using the Ehrlich reagent against the background of taking Etodolac, a false positive result (the presence of phenolic metabolites of Etodolac in the urine) may occur.

Use in pediatrics

It should not be used in children under 15 years of age.

Drug interaction.

It is highly associated with blood plasma proteins, when used simultaneously with other drugs that also bind to plasma proteins (eg, anticoagulants), it is possible to enhance the effects of both active substances (dose adjustments are required).
You can buy Etodolac on our website in any quantity.
Etodolac enhances the effects of oral anticoagulants (phenyldione) and heparin.
Etodolac enhances the anti-aggregant properties of ticlopidine (when they are used simultaneously, monitoring the duration of bleeding).
Etodolac may enhance the hypoglycemic effect of sulfonamides.
Etodolac increases the concentration of lithium in blood plasma (with simultaneous use it is necessary to control the concentration of lithium in the blood).
Etodolac enhances hematological toxicity of methotrexate.
With the simultaneous use, Etodolac weakens the action of diuretics.
When combined with other NSAIDs, the risk of peptic ulcer and gastrointestinal bleeding increases.

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