Hydrochlorothiazide

Arterial hypertension, edematous syndrome of different genesis (chronic heart failure, nephrotic syndrome, renal failure, fluid retention in obesity), diabetes insipidus, glaucoma (subcompensated shape).


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Description

Indications for use

Arterial hypertension, edematous syndrome of different genesis (chronic heart failure, nephrotic syndrome, renal failure, fluid retention in obesity), diabetes insipidus, glaucoma (subcompensated shape).

Drug contraindications.

Pronounced renal dysfunction, liver failure, severe forms of gout and diabetes, hypersensitivity to sulfamides.

Dosage is determined individually. Single dose – 25-50 mg, daily dose is 25-100 mg. The frequency of reception depends on the indication and patient response to treatment.

Side effects

From the digestive system: nausea, vomiting, diarrhea; rarely – pancreatitis.

From the cardiovascular system: orthostatic hypotension, tachycardia.

From the metabolic system: hypokalemia, hypomagnesemia, hyponatremia, hypoglycemic aalkalosis, hyperuricemia, hypercalcemia.

From the endocrine system: hyperglycemia.

From the hematopoietic system: rarely – neutropenia, thrombocytopenia.

From the body of the vision: rarely – visual impairment.

CNS and peripheral nervous system: weakness, fatigue, dizziness, paresthesia.

Allergic reactions: rarely – allergic dermatitis.

Drug interactions

Hydrochlorothiazide can be bought on our website.

If you use the antihypertensive drugs, not depolarizing muscle relaxants, their effect will be enhanced.

The simultaneous use of barbiturates, diazepam, ethanol increases the risk of orthostatic hypotension.

The use of corticosteroids raises the risk of developing hypokalemia, and orthostatic hypotension.

The use of ACE inhibitors (i.e. captopril, enalapril) enhances antihypertensive effect.

There is possible severe hypotension, especially after the first dose of hydrochlorothiazide, apparently, by hypovolemia that leads to a transitory increased hypotensive effect of ACE inhibitors.

There is increased risk of renal dysfunction. It does not exclude the development of hypokalemia.

The use of oral hypoglycemic drugs reduces their effectiveness.

The use of calcium and/or vitamin D in high doses can lead to hypercalcemia and the risk of developing metabolic acidosis due to slow excretion of calcium in the urine under the influence of thiazide diuretics.

The simultaneous use of allopurinol increases risk of allergic reactions, especially of patients with impaired renal function.

The simultaneous use with digoxin may increase the risk of glycoside intoxication.

The use of indomethacin, piroxicam, naproxen, phenylbutazone may decrease the hypotensive effect.

The use of irbesartan may develop additive hypotensive effect.

The use of carbamazepine may lead to the development of hyponatremia.

The simultaneous use of colestipol, colestiramin decreases absorption and diuretic effect of hydrochlorothiazide.

The use of lithium carbonate may increase the concentration in blood of lithium salts to toxic levels.

The use of orlistat decreases the efficacy of hydrochlorothiazide, which can lead to a significant increase in blood pressure and development of hypertension.

The use of sotalol may lead to hypokalemia and development of ventricular arrhythmia of “pirouette” type.

Special instructions

Hydrochlorothiazide can be bought in any quantity at the best price.

The drug should be used with caution by patients with gout and diabetes.

Patients with renal failure require monitoring of plasma concentrations of electrolytes and QC.

If you notice signs of potassium deficiency, as well as in case of the simultaneous application of cardiac glycosides, corticosteroids and ACTH, you should take potassium supplements or potassium-sparing diuretics.

Prolonged use should be followed with the diet rich in potassium.

Avoid concomitant use of diuretics with NSAIDs.

Diagnoses

Adrenogenital syndrome

Acromegaly

Gestational diabetes

Gynecomastia in men

Pregnancy and lactation.

There were no adequate and well-controlled clinical studies on safety of hydrochlorothiazide during pregnancy.

Experimental studies have showed no signs of adverse effects on the fetus. Given this, the use during pregnancy is possible only for health reasons and only in the case when the expected benefit to the mother outweighs the potential risk to the fetus.

Hydrochlorothiazide passes into breast milk. It is recommended to avoid use of hydrochlorothiazide during the first month of breastfeeding because there are reports of suppression of lactation.

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