Lynoral

What kind of hormone is Ethinylestradiol? After reception the sex hormone interacts with special estrogen receptors. Synthetic hormone stimulates the proliferation of epithelial tissues in the cervix, vagina, uterine tubes, ducts of mammary glands, external genitalia. The influence of the synthetic hormone increases the degree of sensitivity of the muscles of the uterus and fallopian tubes to the means stimulating the motility.

 


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Description

Pharmacodynamics and pharmacokinetics

What kind of hormone is Ethinylestradiol? After reception the sex hormone interacts with special estrogen receptors. Synthetic hormone stimulates the proliferation of epithelial tissues in the cervix, vagina, uterine tubes, ducts of mammary glands, external genitalia. The influence of the synthetic hormone increases the degree of sensitivity of the muscles of the uterus and fallopian tubes to the means stimulating the motility.

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Lynoral has a hypocholesterolemic effect, increases the concentration of beta-lipoproteins, increases the body’s sensitivity to insulin, and stimulates utilization of sugars. High dosages of the drug are able to keep fluids and Na in tissues of the body, inhibit the formation of red blood cells and decrease the secretion of FSH of the pituitary gland.

In men, this substance causes inhibition of the formation of sperm, leads to the development of atrophic changes in the testes, inhibits the secretion of androgens. When it is combined with other synthetic hormones, the substance possesses contraceptive properties, has weak anabolic activity.

Lynoral¬† is completely absorbed through the mucous membranes and skin. The metabolism of substances occurs through hepatoenteric recycling, which accompanies the effect of “first passage” through the liver, where 2-Ethinylestradiol and 2-methoxyestradiol are later oxidized. Then, the metabolites are subjected to sulfonation reactions and glucuronidation. Products are excreted through the kidneys in urine and bile. The rate of excretion of the tools depends on the physiological state of the patient.

Indications for use

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The drug is used:

for contraception as part of the combined drugs;

to eliminate the negative manifestations of menopause;

for female hypogonadism;

for the treatment of dysmenorrhea;

in the complex treatment of breast tumors during menopause;

for the palliative treatment of malignant tumors of the prostate gland of men.

Drug Contraindications

The drug is not used:

in case if breast cancer and other estrogen- dependent tumors;

if a patient has vaginal bleeding of unknown origin;

in case of herpes in pregnant women, including in the anamnesis;

for the treatment of patients with endometriosis;

by pregnant women;

in case of serious diseases of heart and vessels;

by individuals suffering from hepatic insufficiency;

during lactation;

in case of sickle-cell anemia.

Side effects

Lynoral may cause:

nausea, gastrointestinal disorders, vomiting, liver disease, education stones in the gallbladder, jaundice;

swelling, swelling and breast enlargement, reduction, or on the contrary increase of libido, pain in the milk glands;

disruptions in menstrual cycle, sudden bleeding after drug withdrawal;

reduced tolerance of the body to glucose, weight gain;

indigestion, migraines, headaches and dizziness;

increased risk of thromboembolism, increase of the number of blood clots in the vessels;

hyperpigmentation of the skin, depression.

Lynoral, usage instructions (Method and dose)

Depending on indications, dosage forms and concentrations of active substance, the drug is prescribed at the dosage from 10 mcg to 3 mg per day.

In case of amenorrhea and oligomenorrhea the drug is administered intramuscularly at a dosage of 0.02-0.1 mg per day, 20 days. Then you should move to the use of progesterone to 5 mg daily for 5 days.

In case of dysmenorrhea the treatment starts from the 5th day of the menstrual cycle. They use 0.01-0.03 mg of the synthetic hormone per day (distributed into 3 doses). The duration of treatment is 20 days. The course can be repeated every 2-3 months.

They use 0.02 mg of the drug 3 times a day for the first few days after birth in order to stop lactation. The next 3 days the drug is taken at the dosage of 0.01 mg, 3 times a day, and once you should take 0.01 mg of the substance.

During menopause, women are prescribed taking 0.05 mg of the drug during the day. In case of acne you should take from 0.03 to 0.06 mg per day.

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The treatment of prostate cancer is carried out in combination with other drugs and treatments. The recommended dosage regimen is 0.15-0.3 mg per day, divided into 3 doses. The dosage can be reduced to 0.05 mg daily after stabilization of the patient.

Overdose.

When taking very large doses of this drug you can experience nausea, vaginal bleeding, and vomiting. Treatment is carried out according to the manifested symptoms.

Interaction with other drugs

This medicine may decrease the effectiveness of antihypertensive drugs, hypoglycemic drugs, anticoagulants.

The reception of the drug with carbamazepine, rifampicin, barbiturates, griseofulvin and other drugs that induce liver enzymes may reduce the plasma concentrations of the synthetic hormone.

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