Moduretic

Moduretic is a combined drug, the effect of which is due to the components that make up its composition; has a diuretic and hypotensive effect. Hydrochlorothiazide, a diuretic with an average strength of action, increases the excretion of Na +, Cl-, K +, Mg2 +, bicarbonate; delays Ca2 +, uric acid in the body. Amyloride reduces the excretion of K + and Mg2 +. The combination of the components of the drug reduces the risk of developing hypoglycemia and hypomagnesemia.


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Description

Moduretic – Instruction. Active ingredients: Pharmacological action:

Moduretic is a combined drug, the effect of which is due to the components that make up its composition; has a diuretic and hypotensive effect. Hydrochlorothiazide, a diuretic with an average strength of action, increases the excretion of Na +, Cl-, K +, Mg2 +, bicarbonate; delays Ca2 +, uric acid in the body. Amyloride reduces the excretion of K + and Mg2 +. The combination of the components of the drug reduces the risk of developing hypoglycemia and hypomagnesemia.
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Indications:

Ocular syndrome of various genesis (CHF, nephrotic syndrome, portal hypertension syndrome); arterial hypertension.

Contraindications:

Hypersensitivity, hyperglycemia (K + content in the plasma is more than 5.5 mmol / l), chronic renal failure, childhood, hepatic coma. With caution. Hepatic insufficiency, diabetes mellitus, respiratory or metabolic acidosis (developmental risk), pregnancy, lactation (only according to strict indications).

Side effects:

Hyponatremia, dry mouth, thirst, hyperuricemia, orthostatic hypotension, tachycardia, gastralgia, taste distortion, arrhythmias, headache, dizziness, confusion, depression, insomnia, drowsiness, asthenia, impaired vision, paresthesia, decreased potency, myalgia, arthralgia, nasal congestion, dysuria, nocturia; hyperglycemia, increased urea concentration, hypercreatininaemia; enuresis.

Dosing and administration:

Moduretic is taken internally. With edematic syndrome, the initial dose value is determined by the severity of water-electrolyte metabolism disorders and is 1-4 tablets daily. After achieving the effect – maintenance therapy for 1-2 tablets after 1-2-3 days. With arterial hypertension – the initial dose of 1 / 2-1 tablets daily; After achieving the desired hypotensive effect – 1/2 tablets daily or every other day.

Interaction:

Decreases the reaction to pressor amines, enhances the effect of non-depolarizing muscle relaxants, increases the toxicity of cardiac glycosides. ACE inhibitors increase the risk of hyperkalemia. Ethanol, barbiturates, other antihypertensive drugs and narcotic analgesics increase the severity of hypotensive action. NSAIDs decrease effectiveness. It is not recommended to combine with preparations of Li +, K + and potassium-sparing drugs.
Before using Moduretic, consult a doctor!

Description of active ingredient (INN). Pharmacological action

Combined drug, the effect of which is due to the components that make up its composition; has a diuretic and hypotensive effect. Hydrochlorothiazide, a diuretic with an average strength of action, increases the excretion of Na +, Cl-, K +, Mg2 +, bicarbonate; delays in the body Ca2 +, uric acid. Amyloride reduces the excretion of K + and Mg2 +. The combination of the components of the drug reduces the risk of hypokalemia and hypomagnesemia.

Ocular syndrome of various genesis (CHF, nephrotic syndrome, portal hypertension syndrome); arterial hypertension.

Contraindications.

Hypersensitivity, hyperkalemia (K + content in the plasma is more than 5.5 mmol / l), chronic renal failure, childhood, hepatic coma, C with caution. Hepatic insufficiency, diabetes mellitus, respiratory or metabolic acidosis (developmental risk), pregnancy, lactation (only according to strict indications).

Side effects.

Hyponatremia, dry mouth, thirst, hyperuricemia, orthostatic hypotension, tachycardia, gastralgia, taste perversion, arrhythmia, headache, dizziness, confusion, depression, insomnia, drowsiness, fatigue, blurred vision, paresthesia, decreased potency, myalgia, arthralgia, nasal congestion, dysuria, nocturia; hyperglycemia, increased urea concentration, hypercreatininaemia; enuresis.

Application and dosage.

Inside. With edematic syndrome, the initial dose value is determined by the severity of water-electrolyte metabolism disorders and is 1-4 tablets daily. After achieving the effect – maintenance therapy for 1-2 tablets after 1-2-3 days. With arterial hypertension – the initial dose of 1 / 2-1 tablets daily; after achieving the desired hypotensive effect – 1/2 tablets daily or every other day.
By purchasing Moduretic on our website, you will receive a quality product.

Interaction.

Decreased response to pressor amines enhances the effect non-depolarizing miorelaxants, increases the toxicity of cardiac glycosides.

ACE inhibitors increase the risk of developing hyperglycemia.
Ethanol, barbiturates, other antihypertensive drugs and narcotic analgesics increase the severity of the hypotensive action.

NSAIDs decrease effectiveness.
It is not recommended to combine with preparations of Li +, K + and potassium-sparing drugs.

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