Indications for use of Plendil are angina, hypertension, and Raynaud’s syndrome. In the last case the medication is used for the symptomatic treatment.
Plendil acts on the body as anti-anginal and antihypertensive drug, inhibits the flow of calcium ions in the smooth muscles of blood vessels, lowers blood pressure, increases coronary and renal blood flow. Depending on the dose it can have anti-ischemic effect.
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Indications for use
The drug is taken for angina.
The therapeutic doses of the drug have no effect on the conductivity and contractility of the heart muscle, are selectively active against smooth muscle cells of arterioles. Plendil has weak natriuretic and diuretic effect; the drug does not provoke fluid retention in the body.
The drug acts during the day, starting to “work” in 2-5 hours after administration, and it is completely absorbed from the gastrointestinal tract and then metabolized in the liver.
What are the release form and composition of the drug?
Plendil is available in the form of tablets of prolonged action, film-coated of 2.5 mg, 5 mg and 10 mg.
The active substance is felodipine; auxiliary means are paraffin, ethanol, iron oxide, anhydrous lactose, polyethylene glycol, purified water and others.
How should it be applied?
It should be remembered that this drug can be prescribed only by a doctor! They pick up the dose individually for each patient. Usually the reception of Plendil starts with 5 milligrams per day (elderly patients – 2.5 mg).
If there are medical indications, the dosage may be increased to 10 mg, but it can not exceed 20 milligrams in 24 hours.
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The pills should be taken in the morning.
Doctors advise to take pills in the morning with a glass of water (it is not necessary to break or chew them). It does not matter whether the drug is taken before or after after breakfast.
The only thing that doctors suggest is that breakfast should not be saturated fat and consist of “heavy” products.
You must exercise extreme caution during the treatment with Plendil when performing activities that require high concentration and reaction speed.
It is better to stop treatment not abruptly, gradually reducing the dose.
What are the side effects?
Usually the drug does not give appreciable side effects. However, in case of hypersensitivity to the components of Plendil (in particular, to felodipine), patients may experience headaches, dizziness, palpitations, weakness, nausea.
In more rare cases the medication can cause allergic rash, fever, edema, vomiting, depression. The overdose may cause hepatitis, gingival hyperplasia, anemia, impaired vision, severe hypotension, bradycardia.
<h2>Who souldn’t take it?</h2>
The drug is not prescribed to people with tachycardia and hypotension, severe hepatic, renal or cardiac insufficiency, unstable angina, hypersensitivity to dihydropyridine derivatives.
Transferred vascular and cardiogenic shock, acute heart attack (especially the first week after the attack) are also contraindications to the use of “Plendil”. In addition, it is not prescribed to pregnant women, women during lactation and children (until they reach 18 years of age).
How does the product “behave” when interacting with other drugs?
If you are taking other drugs, then you should explore the interaction.
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The simultaneous use of “Plendil” and drugs such as “Cimetidine”, “Erythromycin”, “Ketoconazole” (acting inhibitors of cytochrome P450), slows down the metabolism of the drug in the liver, increasing the content of felodipine in plasma.
The reduction of the level of felodipine in plasma promotes the combination of “Plendil” with barbiturates, phenytoin and carbamazepine.
Caution should be taken in case of simultaneous reception of “Plendil” and pharmaceuticals containing beta-blockers: such a compound significantly increases the odds of development of chronic heart failure.
It is interesting that not only medications can interact with “Plendil” – it has been found that the concentrated juices of grape and grapefruit increase the bioavailability of felodipine almost in three times due to the presence of flavonoids.