Pletal

The drug belongs to a group of medicines called phosphodiesterase inhibitor of the 3rd type. The drug has different effects. This means that it expands some blood vessels and clumping of certain blood cells known as platelets, decrease in blood vessels.


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Description

The drug belongs to the next group

– Thrombocyte aggregation inhibitors excluding heparin.

– Anticoagulants

– Tool for thrombosis (anti-thrombotic agents)

The drug belongs to a group of medicines called phosphodiesterase inhibitor of the 3rd type. The drug has different effects. This means that it expands some blood vessels and clumping of certain blood cells known as platelets, decrease in blood vessels.

Indications for use

Pletal is used for the treatment of occlusion of blood vessel in hands and feet that cause functional limitations. In particular, the drug prolongs painless walking in patients with so-called intermittent claudication.

Intermittent claudication is manifested in cramping pain in the legs when walking. They are caused by insufficient blood supply to the legs. The drug helps to increase the distance you can walk without pain, it improves blood circulation in the legs.

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Pletal 100 mg should not be used by patients undergoing surgery on the coronary vessels during the last six months

Dosage

The drug should be taken 2 times a day

You should take this medication for 30 minutes before or two hours after breakfast and dinner. Related eating is associated with an increase in the concentration of active substance in the blood that may be associated with the increasing number of side effects.

The duration of treatment from 16 to 24 weeks can increase the distance of the walk considerably. The first improvement often comes from 4 to 12 weeks of treatment. If the therapy has no effect after six months, the doctor should consider other treatment options.

Side effects.

Frequent common side effects:

Headache, diarrhoea, change of stool.

The common side effects

Subcutaneous bleeding, water retention in the tissues (face, hands and feet), the surplus blood sugar, diabetes, dizziness, palpitation, tachycardia, angina, abnormal heart rhythms, extra heartbeats chamber, runny nose, throat irritation, nausea and vomiting, indigestion, flatulence, abdominal pain, rash, itching, chest pain, weakness.

Unusual side effects.

Anemia, allergic reactions, anxiety, insomnia, unusual dreams, myocardial infarction, atrial fibrillation, insufficient pumping of the heart, tachycardia (starting above the Atria and from the Atria), loss of consciousness, eye haemorrhage, epistaxis, gastrointestinal bleeding, general circulation, low blood pressure, the body is changing position, difficulty with breathing, pneumonia, cough, inflammation of the stomach, muscle pain, chills.

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Rare side effects

Prolonged time of bleeding, platelet excess, renal failure.

Side effects of unknown frequency

Bleeding, pathological changes in the blood (thrombocytopenia, absence of granulocytes , white blood cells and red blood cells, no granulocytes) a special form of anemia ( aplastic anemia ), refusal to eat, paralysis, sensory disturbances, conjunctivitis , tinnitus, hot flashes, high blood pressure , low blood pressure , brain hemorrhage, pulmonary hemorrhage, flow of muscle blood, bleeding of the respiratory tract, subcutaneous bleeding, a special form of pneumonia (interstitial pneumonia), inflammation of the liver , abnormal liver function, jaundice, eczema, skin rashes, severe skin reactions ( Stevens-Johnson syndrome , toxic epidermal necrolysis ), urticaria, blood in urine, frequent urination, fever , malaise, pain, elevated levels of uric acid in the blood, elevated blood urea, elevated creatinine levels in the blood.

Additional information

Each incident of bleeding or bruising during treatment is reported by a treating physician. The use of Cilostazol should be terminated in case of retinal hemorrhage.

If surgery (removal of teeth) is planned and dilution of blood is not required, Cilostazol should be discontinued for five days before the procedure.

Cilostazol should be terminated immediately in the treatment of pathological changes of the blood. Therefore, patients should pay attention to warning signs, such as fever or sore throat.

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Drug interaction

In accordance with the recommendations of the European Agency of medicines (EMA), you need to exclude the combination of aspirin + clopidogrel or any other combination of anti-platelet therapy with blood thinners (anticoagulants) from the treatment.

Some drugs inhibit the enzyme that reduces Cilostazol in the body. Thus, it can cause increased bleeding, simultaneous introduction of macrolide antibiotics such as erythromycin and clarithromycin , antifungal, ketoconazole and Itraconazole , HIV-1 protease inhibitors (AIDS ), diltiazem (for high blood pressure), some psychotropic drugs, such as fluoxetine or proton pump inhibitors (antacids excess ) of great medical care. If necessary, a doctor will monitor blood clotting more often, or change the dosage. Grapefruit juice should be avoided completely during treatment with the drug, because it also amplifies the effects.

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