The instructions for use of Prazosin
Prazosin is a highly effective medical remedy which can be applied in the implementation of the curative treatment of such diseases as arterial hypertension.
The cure is quite applicable in different forms of manifestation of this disease. It can also be used for therapy in cause congestive heart failure.
Method of reception and doses
You can take this medication regardless of meal.
A patient should start taking the drug with a small dosage of 0.5 – 1 mg per day before sleep and then stay in bed because it can cause the intensive development of the symptoms “of the phenomenon of first dose” – postural hypotension, which may result in fainting.
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There is an especially pronounced reaction of the human body in the background of application of various diuretic drugs. In the future you can increase the dose to 1 mg 3-4 times every day.
The dosage is gradually increased in order to achieve the maximum anti-hypertensive effect. The result of drug action comes after a few days in most cases, but persistent lowering of blood pressure is observed only after 4-8 weeks.
A maintenance dose should be selected separately for each individual case. It can be from 3 to 20 mg per day. Usually it is 6-15 mg. The total number of tablets is divided into 3-4 reception, setting the best course of treatment. Sometimes the drug is active in case of twice reception.
In case of mono therapy, you should pay attention to the possibility of the patient’s early or late tolerance to the medication. In this case, you require an increase in dosing of approximately 1 mg. Also it is practiced the combined appointment of diuretics.
Release form and composition.
The medicine is made in the form of small round tablets.
Its active ingredient is a chemical – prazosin hydrochloride.
Additional substances include: corn starch, magnesium stearate, soluble starch, monohydrate, anhydrous colloidal silicon dioxide, lactose.
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Interactions with other medicines.
Prazosin in combination with other drugs
Prazosin is absolutely incompatible with “Nifedipine”. The effectiveness of the drug is considerably increased by such medications, as various sympatholytics, diuretics, and various beta-blockers.
Combined use with beta-blockers or angiotensin-converting enzyme, blockers of small calcium channels significantly increases the risk of pronounced arterial hypotension.
Vasodilatory effect of calcium channel blockers and alpha-blockers may be synergistic and additive.
The parallel introduction of the drug along with “Verapamil” causes the development of severe arterial hypotension, in part due to the pharmacokinetic action of drugs: increases the maximum concentration and the total concentration of prazosin.
“Indomethacin” can significantly reduce the effectiveness of the medication.
Prazosin usually promotes rapid and significant increase in the number of digoxin contained in the blood plasma. In addition, it can change the antihypertensive action of “Clonidine”.
Patients, who take “Propranolol”, have a risk of manifestation of severe symptoms of hypertension after the first dose.
Prazosin can be prescribed to almost all patients with the exception of a few cases:
A patient hasn’t reached the age of twelve.
Pregnant women and in the period of breastfeeding.
The manifestation of signs of constructive pericarditis.
Heart disease, which is characterized by a decrease in pressure when filling the left ventricle.
Intensive development of hypotension.
Obvious symptoms of tamponade of heart.
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The drug can be taken with extreme caution and in reduced dosages by people suffering from various kidney diseases. Treatment should be carried out under the strict supervision of the attending doctor.
The drug shouldn’t be accepted by patients with allergies to components of the medication.