Premarin

Premarin is a conjugated estrogen drug, used to relieve the symptoms of menopause (like hot flushes, perspiration and vaginal dryness). The use of this drug may prevent the decrease of bone density that usually happens after menopause and may lead to such disease as osteoporosis. Premarin is available in the form of tablets that must be taken daily. Patients who haven’t had a hysterectomy, Premarin is usually prescribed together Progestogen to protect the uterus.


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Description

Premarin is a conjugated estrogen drug, used to relieve the symptoms of menopause (like hot flushes, perspiration and vaginal dryness). The use of this drug may prevent the decrease of bone density that usually happens after menopause and may lead to such disease as osteoporosis. Premarin is available in the form of tablets that must be taken daily. Patients who haven’t had a hysterectomy, Premarin is usually prescribed together Progestogen to protect the uterus.

How does this drug act?

Premarin is a mixture of estrogen hormones, i.e. it consists of a number of various kinds of estrogens from natural sources. Estrogen is produced naturally by the ovaries and takes part in the numerous processes. That’s why menopause may cause a lot of unpleasant vaginal symptoms, such as hot flushes, perspiration, dry vagina, lack of libido, leakage of urine and lack of bone density.

Advantages of Premarin

Premarin is intended to relieve the following symptoms of menopause:

Dry vagina
Itching
Hot flashes
Loss of bone mass caused by the drop in the level of estrogen

The reduction of estrogen levels can increase the risk of certain diseases, such as osteoporosis (when you bones become weak).

Other advantages of Premarin are:

It allows you to avoid heart problems
It helps to prevent the cancer of uterus

How should I take the drug?

The dose of Premarin ranges from person to person. However, the common initial dose is 1 pill a day. Unlike some other hormone replacement treatments, Premarin must be taken uninterruptedly throughout the menstrual cycle.

The dose depends on your reaction to the drug and the severity of your symptoms. Usually, a doctor prescribes the lowest efficient dose, which means that you should start the treatment with the smallest dose, and then increase it gradually to avoid adverse effects.

If you didn’t have a hysterectomy, you’ll have to take progestogen together with Premarin. In this case, you should take several days break from the estrogen therapy before starting the treatment with Premarin.

Dosage

Premarin comes in the following doses: 300 mcg, 625 mcg and 1.25mg. Usually, the initial dose is 300 mcg.

These doses have been created by the company Pfizer to provide the maximum effect and minimize the risk of adverse effects.

Premarin is also available in the form of cream for the treatment of the unpleasant vaginal symptoms.

Adverse effects

Even though Premarin rarely causes any side effects, you should remember that Premarin is a HRT drug, and because of the changes in hormone levels, it may enhance the risk of certain diseases.

The use of Premarin or estrogen drugs may enhance the risk of stroke, heart failure, breast cancer and blood clotting. Therefore, the drug should be taken only on the doctor’s prescription.

Possible adverse effects

Head pain
Stomachache
Sickness
Anxiety
Pain in the muscles and joints
Vaginal hemorrhage

Some patients have experienced light bleeding and decreased libido.

Precautions

Premarin can be ordered only by the women who have the doctor’s prescriptions and visit the specialists regularly. You should avoid taking this drug in the following cases:

If you suffered from breast cancer, endometriosis, tumors of uterus, etc.
If you’re taking anti-seizure drugs, medications for tuberculosis or AIDS or Metopirone.

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