Proscar

Benign prostatic hyperplasia (BPH) is an enlarged prostate with benign nature. The prevalence of this disease in different age groups is uneven: the disease is usually diagnosed after reaching 40-50 years of age, about 80-90% of men of 60 years of age have an enlarged prostate gland.


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Description

Benign prostatic hyperplasia (BPH) is an enlarged prostate with benign nature. The prevalence of this disease in different age groups is uneven: the disease is usually diagnosed after reaching 40-50 years of age, about 80-90% of men of 60 years of age have an enlarged prostate gland. Over 50 % of men turn to the doctor for benign prostatic hyperplasia in connection with the affiliated problems with urination. Currently the pharmaceutical market has a wide selection of medications to control the clinical manifestations of hyperplasia of prostate. One of the popular drugs is Proscar tablets.

Proscar is a drug with antiandrogenic effect. The active ingredient of the medication (finasteride) belongs to the pharmacological group of competitive inhibitors of 5-alpha-reductase. The specified enzyme converts the male sex hormone testosterone to the more active steroid dihydrotestosterone. High concentration of DHT is the main factor in the progressive enlargement of the prostate. Finasteride slows the disease progression and even leads to a reduction of prostate volume, reducing the number of active androgen.

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The instructions for use

The drug Proscar has undergone many clinical trials. A little bit of facts.

In accordance with the materials of clinical trials of the drug (PLESS), finasteride had a significant impact on the likelihood of developing of acute urinary retention (7 to 3 %), reduced the need for operative treatment of hyperplasia of prostate in 2 times (from 10 to 5 % of subjects). All study participants noticed a decrease in the size of the prostate (on average 20 % of the original volume), the increase of the flow velocity of urine during the 4-year observation period;

Clinical MTOPS study, which lasted for 6 years, has evaluated the comparative effect of treatment with finasteride (5 mg per day), doxazosin ( 4 /8 mg daily), a combination of both drugs. It analyzed the following factors: the risk of acute urinary retention, risk of progression of the disease. The best results for the above parameters were observed in the treatment finasteride and combination of drugs (the risk reduction on average 40 and 60 %, respectively).

In accordance with the instructions for use, the drug has a unique indication for the purpose the treatment of hyperplasia of prostate.

Drug contraindications

The age of 18;

Individual intolerance to the components included in the product (except for active substances, it includes lactose, corn starch, povidone, magnesium stearate, cellulose, iron oxide and other components);

Caution should be used in case of a large amount of residual urine, severe violation of the outflow.

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Side effects

All side effects of the drug can be divided into groups ( according to body systems exposed to unwanted action of the drug):

The most unpleasant reactions develop as a result of exposure on the reproductive system of men (pain in the testicles, erectile dysfunction, reduced sexual desire and problems with ejaculation (violation of the process, decrease the amount of semen);

Endocrinological disorders (engorgement, increase, breast tenderness);

Mental health (depression);

Effects on the cardiovascular system (palpitations);

Hypersensitivity reactions (rash, pruritus, angioedema);

Liver disorders (increased level of ASAT, ALAT);

The changes in some laboratory parameters (decrease in level of prostate specific antigen).

Worth noting: side effects are rare. The most common undesirable effect is impotence (1-10% treated with finasteride).

In case of long-term therapy, the severity of erectile dysfunction gradually decreases. Several studies have demonstrated a lower risk of developing prostate cancer with long-term therapy with finasteride.

There is a small quantity of substance in the semen, but it is unknown what consequences a finasteride may have and its effects on the female body.

The application of Proscar revealed no significant interactions of it with other drugs (compatible with any drugs).

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How should you take the drug?

Proscar is taken 1 times per day regardless of time of food intake: 1 tablet contains 5 mg of the active substance.

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