Singulair

Montelukast is an active component of the preparation Singulair. It selectively inhibits leukotriene receptors of the epithelium of bronchopulmonary tissue, making them immune to the action of cysteinyl leukotrienes. Singulair prevents bronchospasm, sputum production, increased vascular permeability, and an increase in the number of eosinophils.


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Description

Pharmacological action of Singulair.

Montelukast is an active component of the preparation Singulair. It selectively inhibits leukotriene receptors of the epithelium of bronchopulmonary tissue, making them immune to the action of cysteinyl leukotrienes. Singulair prevents bronchospasm, sputum production, increased vascular permeability, and an increase in the number of eosinophils. This is due to the fact that cysteinyl leukotrienes are proastmatic mediators. When they bind to receptors, symptoms of asthma and allergic rhinitis are manifested.
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Blocking receptors Singulair causes relaxation of the bronchi within 2 hours after admission, reduces the content of intra- and extracellular factors of inflammation in the airways, the reactivity of the bronchi. This way it suppresses the bronchospasm of various stages (early and late), significantly reduces the concentration of eosinophils.

Indications for use.

Chewable tablets (4 mg, 5 mg) are prescribed in pediatrics (children 2-14 years) for:
– treatment of asthma (against the background of insufficient GCS effect or intolerance to GCS);
– prevention of asthma attacks (including before physical exertion);
– relief of allergic rhinitis.
Singulair is used as an alternative to GCS in the absence of seizures for a long time.
Tablets coated with a coating (10 mg) are prescribed for patients older than 15 years for:
– additional therapy of asthma with insufficient effectiveness of other agents (GCS, β-adrenoreceptor agonists);
– treatment of seasonal rhinitis;
– prevention of seizures.
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Mode of application.

Dose for patients from 15 years – 10 mg / day (1 tablet of Singulair 10 mg). It is taken in the evening out of eating. The tablet should be washed down.
Children 2-5 years: 1 tablet of Singulair 4 mg / day. Children 6-14 years: 1 tablet of Singulair 5 mg / day. The tablet is chewed out of food in the evening.
At an allergic rhinitis the time of reception is defined by the doctor.

Side effects.

On the background of receiving the Singulair, the following undesirable reactions can occur: – thirst; – increased bleeding; – anaphylaxis; – angioedema; – eosinophilic hepatic infiltration; – drug-induced hepatitis, cholestatic hepatitis; – drowsiness; – paresthesia; – aggression, irritability; – unusual dreams; – hallucinations; – insomnia; – asthenia; – suicidal thoughts; – cramps, tremors, muscle spasms; – pancreatitis; – dyspepsia, pain in epigastrium; – myalgia, arthralgia; – swelling; – bruising pain; – nodal erythema, urticaria; – itching of the skin; – tachycardia; – development of Churg- Strauss syndrome.

Contraindications.

Singulair is contraindicated in pediatrics in children under 2 years of age. In case of hypersensitivity to montelukast, its structural analogs, auxiliary components of the drug, the use of Singulair should be abandoned.

Pregnancy.

According to the doctor’s decision, it is possible to apply Singulair during pregnancy. It should be borne in mind that in the post marketing period, cases of birth defects of limbs in children whose mothers received montelukast treatment were established, although there was no direct proven relationship with the drug.
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Drug interaction.

Singulair potentiates the action of loratadine. The use of phenobarbital reduces the effect of montelukast by 40%. No other significant interactions were observed.

Overdose.

Symptoms of overdose: thirst, epigastric pain, headache, drowsiness, psychomotor agitation, vomiting. Treatment is symptomatic. The effectiveness of hemodialysis in case of an overdose of Singulair is not known.

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