Why do we use Tadalafil?
This is the question we will answer in this article about Tadalafil. To date, the pharmaceutical market offers many medications to combat erectile dysfunction. Various dietary supplements on the plant base in most cases have a weak effect, so the preference is better given to medicines. Tadalafil on their background favorably stands out.
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Mechanism of action.
The first drug that was prescribed to treat erectile dysfunction is Sildenafil, better known under the trade name Viagra. Therefore, it is considered a kind of “gold standard”, with which the effectiveness of other medicines to increase potency is compared. Then came Vardenafil (or Levitra), which, by and large, was no different from Sildenafil.
More recently, a new drug, Cialis, was developed, based on the tadalafil. But these tablets favorably have a longer effect (up to 36 hours) than their counterparts can’t “boast”.
The researchers’ testimonies indicate that all the tablets mentioned above act on the body in the same way. Physiologically, the erection is caused by the relaxation of the muscles and filling the blood of the cavernous bodies that are in the penis. Simultaneously, the outflow of blood from it is blocked, the penis hardens and increases in size.
This process begins under the influence of impulses from the brain, which arise in response to the sexual arousal of a man. Relaxation of muscle fibers and expansion of arterial blood vessels occurs under the influence of an enzyme called cyclic guanosine monophosphate (cGMP). At the end of sexual intercourse cGMP is destroyed under the influence of another substance – phosphodiesterase type 5 (PDE 5). The outflow of blood from the penis is restored, and the erection stops.
With erectile dysfunction, destruction of cGMP occurs much earlier than it is required for a normal sexual act. The action of substances such as tadalafil, sildenafil and vardenafil, is aimed at inhibition of PDE 5. Thus, a persistent erection is provided. However, the effectiveness of these drugs is guaranteed only when there is a sexual attraction. Otherwise they simply will not work.
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Only in 20% of cases erectile dysfunction is caused by various psychological problems. In such a situation, the doctors’ testimonies say that one should not rush with taking various medications. Sometimes there is enough competent consultation of the psychologist and use of herbal remedies.
In almost all of these cases, Tadalafil and its analogs will help to cope with erectile dysfunction. But it is necessary to note: the instruction on their application provides for restrictions to use in certain diseases.
Instructions for use indicate that the capsule should be taken at least 15-20 minutes before the sexual intercourse. The doctors’ comments indicate that the drug can last up to 36 hours, but daily medication is allowed.
For regular admission, Tadalafil 20 mg is recommended, but with a mild form of renal, hepatic insufficiency, and also during treatment with certain antibiotics and antifungal agents, it is necessary to reduce the dosage to 10 mg once every three days. If necessary, simultaneous reception of two capsules, but the maximum daily dose of the active ingredient of the drug should not exceed 40 mg.
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In our body, in addition to phosphodiesterase of the fifth type, there are also other kinds of this enzyme. For example, PDE-6 regulates the work of the retina, and PDE-3 – the heart. PDE is also present in skeletal muscles and lungs. Although Tadalafil has a greater effect on PDE-5, it also inhibits the enzyme in other organs. This is what determines the main and most common side effects of erectile dysfunction.
Instructions for use describe in detail, in which cases these tablets are strictly prohibited. They can’t be taken simultaneously with medicines that contain nitrates, and with means to lower blood pressure. These are Nitroglycerin, Tivortin, Vasotropin, Phentolamine, Doxazosin, etc. As a result of simultaneous administration of these drugs, a sudden uncontrolled lowering of blood pressure can occur, which is dangerous to health and can even end in a fatal outcome