Viagra

Viagra pills belong to the pharmacological group of drugs used to treat erectile dysfunction of men. The drug does not affect erectile mental dysfunction of central origin.


Description

Viagra pills belong to the pharmacological group of drugs used to treat erectile dysfunction of men. The drug does not affect erectile mental dysfunction of central origin.

Release form and composition.

Viagra can be bought on our website. It is available in the form of coated tablets. One tablet contains the main active ingredient of sildenafil (as the citrate) in a few dosages – 25, 50 and 100mg.

Tablets are packaged in blisters of 1, 2, 4 and 12 pieces. Cardboard pack contains one blister with the appropriate number of pills and instructions for use. Viagra can be bought on our website.

Pharmacological action

The main active substance of Viagra has an effect on the development processes of erection of men during the emergence of sexual arousal, by increasing blood flow to the cavernous bodies of the penis. Sildenafil inhibits the enzyme camp-specific phosphodiesterase type 5 (PDE5). This leads to an increase in the concentration of cyclic amp (cyclic adenosine monophosphate) which causes the relaxation of smooth muscles of the walls of blood vessels and corpora cavernosa of the penis and increases their filling with blood resulting in an erection. Also, the local excitation produces nitric oxide (NO), which stimulates an increase in camp concentration. It is believed that the active substance of tablets of Viagra enhances the effect of nitric oxide. The main condition for the existence of the effect of the use of this drug is the presence of sexual stimulation of the man and its arousal.

After intake of a pill of Viagra, sildenafil is rapidly absorbed into the blood from the lumen of the small intestine. Its therapeutic concentration is achieved through half an hour after taking the tablet, the maximum concentration is achieved after 1 hour. If you take a tablet orally after meals, the rate of absorption will slightly lower than on an empty stomach. Sildenafil is evenly distributed in all tissues. Its metabolism occurs to the hepatocytes (liver cells) with the formation of intermediate breakdown products that are excreted in the feces (90%). The elimination half-life (the time during which the organism excretes half the dose) is 4 hours.

Indications for use

The main indication for use of Viagra is the correction of sexual erectile dysfunction of men to achieve penile erection which is sufficient for intercourse. An important condition for achieving results is the presence of male sexual arousal. Viagra can be bought on our website in any quantity.

Drug Contraindications

The use of the tablets Viagra is contraindicated in case of some pathological conditions, which include:

Individual intolerance or hypersensitivity to Sildenafil or auxiliary components of the drug;

Simultaneous use of tablets Viagra and other drugs that include nitric oxide donors, which can potentiate the hypotensive effect and lead to a significant reduction in systemic arterial pressure;

The state of the male body, when sexual activity is unwanted – severe cardiovascular pathology, coronary heart disease, stable or unstable angina, presence of acute or chronic heart failure.

The loss of vision of one eye due to ischemic neuropathy of the optic nerve, regardless of the relationship of this pathology with the previous use of drugs or compounds which are inhibitors of the enzyme PDE5;

the presence of cardiovascular diseases, which are accompanied by a decrease in systemic blood pressure (hypotension);

Concomitant hepatic or renal insufficiency;

Hereditary degenerative pathology of the retina;

Recent myocardial infarction or stroke in the brain;.

The presence of contraindications should be determined before beginning application.

Method of application and doses

Viagra pill is taken orally, regardless of meal (bioavailability and rate of absorption of the active substance of the drug from the intestine on an empty stomach is higher). The pill must be taken immediately after extraction from blister, and the prolonged exposure to air can reduce the concentration and activity of sildenafil. Also, it is recommended to hold a tablet in the mouth until the softening and then swallow it, the passage of tablets through the esophagus can be taken with a small amount of liquid. The recommended dose is 50 mg, if necessary it can be increased to 100 mg The maximum daily dose is 100 mg. Viagra should be taken for 1 hour before the expected sexual activity in order to achieve good result. If you have hepatic insufficiency, the dose of the taken drug should be reduced to 25 mg.

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