Topamax

Topamax (Topiramate) belongs to the group of antiepileptic drugs, which block sodium channels, prevent anxiety and relieve spasms. The medicine is efficient for the treatment of epilepsy, migraine headache and cramps. The drug has spasmolytic, painkilling and anti-inflammatory effect.


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Description

Topamax (Topiramate) belongs to the group of antiepileptic drugs, which block sodium channels, prevent anxiety and relieve spasms. The medicine is efficient for the treatment of epilepsy, migraine headache and cramps.

The drug has spasmolytic, painkilling and anti-inflammatory effect.

Adverse effects

Topamax may cause certain adverse effects, including:

digestive system – loose bowels, vomiting, sickness, weight change, lack of appetite;
CNS – mental confusion, head pain, vertigo, sleepiness, weakness, depressive disorder, hallucinations, excitement;
mental disorders – speech impairment, excitement, mental confusion, loss of orientation, adverse reactions, mood swings, anxiety, depression, irritability, behavioral changes;
sensory organs –vision impairment, nearsightedness, eye irritation, high intraocular pressure;
allergic responses – urticaria, itching, inflammatory diseases of the mucous membranes, swelling and dermatitis;
infections, such as nasopharyngitis;
blood and lymphatic system – anemia, low white blood cell count, adenopathy, low platelet count or eosinophilia;

Precautions

Topamax is used for the treatment of:

increased sensitivity and intolerance to the drug elements;
liver dysfunction or coronary insufficiency;
serious brain disorder;
cancer;
pregnancy and breastfeeding.

People with kidney dysfunction and osteoporosis must use the drug with caution.

Dosage

Take the drug by mouth, irrespective of the mealtime.

Topamax should be swallowed whole or taken together with a small amount (about 1 tsp) of soft meal.

The initial dose is 25 mg a day. However, the dose depends on your health state.

Capsules are intended for the people who have problems with swallowing pills (for instance, kids and older patients).

Drug interactions

Mixing Topamax with other AEDs (phenytoin, carbamazepine, valproic acid, phenobarbital, primidone) can’t affect the rate of CSS in blood plasma. It is essential to control the phenytoin concentration.

Phenytoin and carbamazepine decrease the concentration of topiramate in blood. The dosage depends on the development of the desired effect.

Skipping the dose

Take the pill as soon as possible. However, avoid taking the double dose to compensate for the skipped one.

Overdose

The signs of overdose are: convulsions, sleepiness, speech disorders, vision impairment, double vision, affected judgment, loss of coordination, lethargy, stupor, low blood pressure, stomachache, vertigo, anxiety and depression.

In case of overdose, take activated carbon. You may also require symptomatic treatment and hemodialysis.

You should carry out usual activities, focused on the maintenance of breathing function and cardiovascular system.
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